Pharmaceutical Services

ImQuest BioSciences has integrated medicinal chemistry, LC-MS analytical and bioanalytical chemistry and NMR services as a component of our PharmaSENS platform to enable the rapid development of a safe, effective, and successful pharmaceutical products. These services are available for small molecules, natural products, oligonucleotides and other biologic products. Our synergistic approach helps facilitate more rapid movement of a potential drug from hit to lead screening, to candidate identification, and IND-directed in vitro/in vivo studies. PharmaSENS allows the optimization of a pharmaceutical product identified in efficacy and toxicity screening and provides ongoing support for PK/PD studies. Contact us to learn more.

Medicinal Chemistry Services

With decade of experience, our professional and technical team has expertise in diverse therapeutic areas including hit-to-lead evaluation and validation, to lead selection and IND-enabling preclinical development. Our medicinal chemistry services include the following:

  • Design & synthesize new analogs
  • Develop Intellectual Property
  • Patent expansion on current commercially available or clinical stage molecules
  • "Patent evergreening" / analysis
  • Computational chemistry support
  • Competitive analysis
  • Product development support from bench to clinic
  • Troubleshooting specific optimization issues including impurity profile analysis
  • Creating compound candidate profiles

Bioanalytical Chemistry

  • Proprietary assays and method development to analyze a wide range of samples including but not limited to:
    • Blood Plasma
    • Serum
    • Tissue
    • Urine
    • Feces
    • Raw Materials
    • Formulated Products
    • Environmental Samples
  • Pharmacokinetics (PK) Services
    • Advanced Bioanalytical Method Development, Method Transfer and Method Qualification
    • Extensive bioanalytical capabilities for analyzing biological tissues (brain, tumor, muscle, liver, kidney, heart)
    • PK/PD models also available:
      • Antiviral infection models
      • Antimicrobial infection models
    • GLP-compliant Immunoassay Validation and Development

Analytical Chemistry Services

  • NMR Spectroscopy Capabilities
    • We provide NMR Spectroscopy as part of our R&D and GMP – GLP services utilizing a Bruker 400 MHz spectrometer:
      • 1-Dimensional Experiments: 1H, 13C, 19F, 31P, 29Si, 15N, 11B, DEPT, NOE and more
      • 2-Dimensional Experiments: COSY and NOESY (1H-1H) , HSQC and HMBC (typically 1H-13C), DOSY and more
      • Variable temperature (-120°C to 120°C)
    • Utilize these Services to
      • Identify impurities by HPLC and LCMS
      • Isolate an impurity by prep-HPLC or flash chromatography
      • Characterize an impurity by NMR and exact mass spectrometry
      • Confirm the identity of an impurity by organic synthesis:
  • Liquid Chromatography Mass Spectrometry (LC-MS/MS) Capabilities
    • Rapid, robust and sensitive detection of a wide range of molecules in environmental and biologic samples
    • Support for in vivo PK studies
    • Advantages of Tandem LC-MS (LC-MS/MS)
      • Enhanced precision and sensitivity
      • Uses dual mass detectors to filter and detect byproducts
      • Increased specificity of analyte identification and reduced limit of detection
      • Essential to applications in the fields of drug metabolism, pharmacokinetics, and biological analyses
      • Expands our efficiency and throughput in experiments involving the analysis of urine, plasma, and other tissue samples