ImQuest BioSciences has integrated medicinal chemistry, LC-MS analytical and bioanalytical chemistry and NMR services as a component of our PharmaSENS platform to enable the rapid development of a safe, effective, and successful pharmaceutical products. These services are available for small molecules, natural products, oligonucleotides and other biologic products. Our synergistic approach helps facilitate more rapid movement of a potential drug from hit to lead screening, to candidate identification, and IND-directed in vitro/in vivo studies. PharmaSENS allows the optimization of a pharmaceutical product identified in efficacy and toxicity screening and provides ongoing support for PK/PD studies. Contact us to learn more.
Medicinal Chemistry Services
With decade of experience, our professional and technical team has expertise in diverse therapeutic areas including hit-to-lead evaluation and validation, to lead selection and IND-enabling preclinical development. Our medicinal chemistry services include the following:
- Design & synthesize new analogs
- Develop Intellectual Property
- Patent expansion on current commercially available or clinical stage molecules
- “Patent evergreening” / analysis
- Computational chemistry support
- Competitive analysis
- Product development support from bench to clinic
- Troubleshooting specific optimization issues including impurity profile analysis
- Creating compound candidate profiles
Bioanalytical Chemistry
- Proprietary assays and method development to analyze a wide range of samples including but not limited to:
- Blood Plasma
- Serum
- Tissue
- Urine
- Feces
- Raw Materials
- Formulated Products
- Environmental Samples
- Pharmacokinetics (PK) Services
- Advanced Bioanalytical Method Development, Method Transfer and Method Qualification
- Extensive bioanalytical capabilities for analyzing biological tissues (brain, tumor, muscle, liver, kidney, heart)
- PK/PD models also available:
- Antiviral infection models
- Antimicrobial infection models
- GLP-compliant Immunoassay Validation and Development
Analytical Chemistry Services
- NMR Spectroscopy Capabilities
- We provide NMR Spectroscopy as part of our R&D and GMP – GLP services utilizing a Bruker 400 MHz spectrometer:
- 1-Dimensional Experiments: 1H, 13C, 19F, 31P, 29Si, 15N, 11B, DEPT, NOE and more
- 2-Dimensional Experiments: COSY and NOESY (1H-1H) , HSQC and HMBC (typically 1H-13C), DOSY and more
- Variable temperature (-120°C to 120°C)
- Utilize these Services to
- Identify impurities by HPLC and LCMS
- Isolate an impurity by prep-HPLC or flash chromatography
- Characterize an impurity by NMR and exact mass spectrometry
- Confirm the identity of an impurity by organic synthesis:
- We provide NMR Spectroscopy as part of our R&D and GMP – GLP services utilizing a Bruker 400 MHz spectrometer:
- Liquid Chromatography Mass Spectrometry (LC-MS/MS) Capabilities
- Rapid, robust and sensitive detection of a wide range of molecules in environmental and biologic samples
- Support for in vivo PK studies
- Advantages of Tandem LC-MS (LC-MS/MS)
- Enhanced precision and sensitivity
- Uses dual mass detectors to filter and detect byproducts
- Increased specificity of analyte identification and reduced limit of detection
- Essential to applications in the fields of drug metabolism, pharmacokinetics, and biological analyses
- Expands our efficiency and throughput in experiments involving the analysis of urine, plasma, and other tissue samples
