Mechanism of Toxicity Analysis

As a key component of our preclinical services program, ImQuest BioSciences has assembled and validated a panel of in vitro and ex vivo toxicity and mechanism of toxicity assays to evaluate the toxicity and off-target effects of new therapeutic entities and to define mechanism of toxicity.

Prior to IND-enabling in vivo toxicity studies, in vitro and ex vivo toxicity and mechanism of toxicity assays allow prioritization of lead compounds, select lead compounds for pilot in vivo efficacy studies, and assist in the design of in vivo safety studies.

We can evaluate the effect of test compounds on the cell cycle, mitochondrial respiration and function, apoptosis, membrane integrity and oxidative stress. Additional assays may explore effects on cellular kinases, growth factors and signal transduction pathways. Multiparameter flow cytometry can also be utilized to further elucidate compound mechanism of toxicity.

Don’t see the assay you are looking for?  Contact or technical team.  We can explore assay transfer or internalization from a pre-developed or published method and perform a feasibility review.

Cytotocity and Mechanism Assays Click Here

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We would love to hear more about your research and development needs. Contact us and we can coordinate a discussion with one of our technical directors to better understand your needs and develop a customized solution.

Can’t find what you are looking for? Reach out to us, we can help.

Explore Additional Services

The ImQuest scientific team has extensive expertise in the development of small molecules, natural products, biologics and vaccines for the treatment and prevention of infectious disease, cancer, and inflammatory disease. Explore our additional service offerings, or reach out to schedule a consultation.

Our Mission

Our goal is to help our clients accelerate their research and development efforts leading to the successful development of new products for the prevention and treatment of human disease. We have a very specific mission; accelerate your research and development plans and provide robust data in support of your projects.