Zika, Dengue and Emerging Virus Services

ImQuest BioSciences provides zika and dengue antiviral drug testing services to help our clients identify products that inhibit the replication of viruses in vitroex vivo and in vivo models. Our staff has decades of experience providing quality, efficient and cost-effective services.

Panels of mosquito borne viruses are available for antiviral testing.

Our services are available for the evaluation of small molecules, natural products, immune modulators, biologics and therapeutic antibodies and provide necessary support from initial discovery, structure-activity relationship evaluation, lead identification and IND-directed preclinical development.

Customized In Vitro Assay Development

Advance your drug development program with ImQuest Biosciences’ IND-directed antiviral services for mosquito borne viruses, including zika, dengue, chikungunya, west nile and yellow fever virus.

Our suite of in vitro assays includes virus screening assays as well as assays to evaluate promising drug candidates for their range of action, efficacy in drug combinations, potential for resistance selection, and phenotypic/genotypic characterization of resistant strains.

For in vivo efficacy studies, we offer access to mouse and non-human primate zika and dengue virus models.

Assays using primary cells are available upon request.

High Titer Virus Stock Production

ImQuest BioSciences provides technical services for the production of high titer and highly infectious virus stocks for both laboratory and clinical strains. We can propagate, concentrate, and characterize at scales ranging from milliters to liters, saving you time and avoiding the tedious steps required for virus production. Whatever your needs, our scientists will customize the virus production process to your specifications.

Virus Production Services include:

  • Production of crude virus preparations for clinical and laboratory derived strains
  • Concentration of virus from crude preparations utilizing Tangential Flow Filtration (TFF)
  • Determination of virus concentration by qPCR and TCID50 determinations
  • Preparation of inactivated virus
  • Isolation of viral proteins, RNA & DNA
  • Quantification of proteins and nucleic acids

Documentation of final viral titer is provided with each lot of virus produced. Infectious virus in each pool may also be quantified by TCID50. Virus can be shipped domestically and internationally, and we are certified for the shipment of Category A and Category B Infectious Substances.

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Request a Scientific Consultation

We would love to hear more about your research and development needs. Contact us and we can coordinate a discussion with one of our technical directors to better understand your needs and develop a customized solution.

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Explore Additional Services

The ImQuest scientific team has extensive expertise in the development of small molecules, natural products, biologics and vaccines for the treatment and prevention of infectious disease, cancer, and inflammatory disease. Explore our additional service offerings, or reach out to schedule a consultation.

Our Mission

Our goal is to help our clients accelerate their research and development efforts leading to the successful development of new products for the prevention and treatment of human disease. We have a very specific mission; accelerate your research and development plans and provide robust data in support of your projects.