Model Overview: Neutropenic Thigh Efficacy Model

Following initial in vitro screening, transition your compound evaluation to in vivo models. This model allows the quantitative evaluation of antibacterial and antifungal agents utilizing different dosing regimens. This model is readily available for testing both wild type and resistant bacterial strains based on the needs of our clients.

Applications

• Determination of in vivo efficacy of candidate antimicrobial drugs against clinical and antibiotic resistant strains
• Comparison of antimicrobial agents with FDA approved compounds of similar class
• Modulation of antibiotic time of addition
• Parallel assessment of PK/PD measurements, dose and dosing interval related to efficacy and the emergence of antibacterial resistance

Assay Customization

Numerous wild type, resistant, and clinical strains are available for use in the mouse model. While the model has been optimized with a representative strain, initial pilot studies to assess bacterial inoculum and growth kinetics are often necessary.

Client derived laboratory or clinical strains can be utilized in the model upon request.

Route of drug administration, selection of positive control, duration of assay, animal dosing regimen, and assay endpoints assessed can be customized.

Contact us to learn more and let our microbiology and in vivo modeling experts help design and implement a study to fit your needs. Custom in vivo models are also available upon request.