ImQuest Microbiology ESKAPE Antibacterial MIC

Microbiology Services

Services for Antibacterial and Antifungal Discovery and Development

ImQuest BioSciences has developed a full service antibiotic development program uniquely combining in vitro, ex vivo and in vivo animal model efficacy, toxicity and mechanism of action evaluations.

We offer in vitro and in vivo services for all of the ESKAPE pathogens, a wide variety of gram positive, gram negative and anaerobic organisms, and fungal organisms. Bacterial Stock production services are also available.

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In Vitro Antibacterial and Antifungal Services

  • CLSI broth-based microdilution for MIC and MBC determination
  • Kill-curve analysis
  • Analysis of bactericidal versus bacteriostatic activity
  • Serum bactericidal effects assay
  • Post-antibiotic effect
  • Anti-Persister Cell Assays
  • Inhibition of biofilm development
  • Minimum Biofilm Inhibitory Concentration (MBIC)
  • Combination antimicrobial evaluations and Fractional Inhibitory Concentration (FIC) determination
  • Resistance selection and characterization
  • Microbial quantification and identification
  • Mechanism of action studies:
    • Macromolecular Synthesis Assays: radiolabelled precursor incorporation analysis
    • In vitro generation and characterization of spontaneous resistance mutations
    • β-lactamase Assays
    • DNA Topoisomerase and DNA Gyrase Assays
  • Bacterial Stock Production Services

In Vivo Evaluation of Antimicrobial Agents

Additional supportive services as part of the ImQuest SUCCESS platform

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ImQuest BioSciences is a preclinical contract research and development organization (CRO) that provides service to evaluate the potential efficacy of new and novel pharmaceutical products for the treatment and prevention of viruses, bacteria, cancer and inflammatory disease, including in vitro toxicology and pharmaceutical product characterization services.