ImQuest CRO Toxicology in vitro


ImQuest's toxicology services quantify the toxicity and off-target effects of potential drug products through a variety of in vitro and ex vivo assays utilizing cell lines and primary cells. These assays provide a focused rational for the continued development of a novel product and identify potential off target effects that that be be explored further in animal safety and toxicology evaluations. Request a quote for Toxicology Services.

Services Available

  • In vitro cytotoxicity in primary cell panels
  • In vitro cytotoxicity in established cell lines
    • In vitro cytotoxicity endpoints:
      • Cell viability
      • Macromolecular synthesis
      • Membrane integrity
      • Apoptosis
      • Cell proliferation
      • Oxidative stress
  • Immunotoxicity Evaluations
  • Flow Cytometric Assays
  • In Vitro Drug Permeability Evaluation
  • In Vitro Metabolism
  • Drug-drug interactions
  • Genomic Toxicology Analysis
  • Pharmacokinetics and pharmacodynamics

To view our white paper on In Vitro Toxicology, click on the link below.

Pharmacokinetic and Pharmacodynamic Evaluations in Animals and Humans

ImQuest BioSciences has the experience to to develop, qualify, validate and perform GLP-compliant immunoassays to support the evaluation of biologics through animal safety/toxicology and human clinical trials. ImQuest BioSciences performs the following immunoassay services for the development of biologic products:

  • Technology transfer of existing assays or development of ELISA or cell-based immunoassays for the detection of biologic products.
  • Feasibility evaluation and continued assay development prior to GLP validation.
  • GLP validation, including accuracy/precision, selectivity, reproducibility, sensitivity and stability, in order to demonstrate the robustness of the assays to provide rigorous and quantitative data.
  • Evaluation of biological samples from small and large animal safety toxicology studies and human clinical trials.
  • Species adaptation of the assay using appropriate biological matrices.

Contact Us to learn more.