Pharmaceutical Formulation and Delivery Services

ImQuest BioSciences has integrated preformulation services and formulation development as a critical component of successful early product development to enable rapid drug formulation and delivery services, focusing on the importance of early-stage pharmaceutical formulation in the rapid development of a safe, effective, and successful therapeutic or prevention product, including small molecules, natural products, vaccines and other biologic products,. In parallel with the investigations of product efficacy and toxicity inherent in the ImQuestSUCCESS platform, this synergistic approach to the drug pipeline development helps facilitate more rapid movement of a potential drug from candidate identification to clinical trials. PharmaSENS assures that the success of a pharmaceutical product identified in the efficacy and toxicity platforms is not derailed by an inability to formulate and deliver an otherwise promising product. Thus, it is critical to consider the pharmaceutical properties of a potential therapeutic or prevention agent as an early component of the development process.

Pharmaceutical Characterization and Preformulation Services

ImQuest BioSciences offers the following services to evaluate the preformulation characteristics, requirements, and potential of a possible pharmaceutical product:

  • HPLC analytical ¬†and bioanlyticial method development
  • API physical characteristics
  • Drug degradation profile and characteristics
  • In vitro drug dissolution - bio-relevant / USP Conditions
  • Drug permeability in tissue and cells
  • Drug solubility
  • Drug and excipient compatibility
  • In vitro / ex vivo drug release testing
  • Moisture content
  • Rheological evaluation
  • Short and long term ICH environmental stability protocols
  • Stability indicating evaluations
  • Development of formulation strategies from preformulation data

Pharmaceutical Formulation Development Services

With the increasing number of novel and specialized compounds being developed, a "one size fits all" approach to drug formulation and delivery is no longer optimal, necessitating the consideration of formulations unique to each drug. ImQuest BioSciences offers formulation programs to compliment drug development programs, and we will work to define the specific characteristics of a product in order to develop a successful formulation.

ImQuest BioSciences has the capabilities to develop the following dosage forms:

  • Oral
  • Intravenous - aqueous and nonaqueous
  • Topical - liquids, semi-solids, and solids
  • Novel formulation and drug delivery

Film and Patch Formulation
ImQuest BioSciences has the expertise and capabilities to develop films and patches for both topical and systemic drug delivery. Vaginal "quick-dissolving" films have been developed for topical microbicide drug delivery. Transdermal patches have been developed for therapeutic drug delivery of anti-viral products.

ImQuest BioSciences' capabilities in film and patch formulation include:

  • R&D formulation manufacturing
  • PharmaSENS preformulation evaluations
  • Formulation dissolution evaluations
  • In vitro and ex vivo drug release
  • Formulation content uniformity
  • Formulation physical characteristic evaluations
  • Formulation moisture content

Nanoparticle Formulation
ImQuest BioSciences has the expertise and capabilities to develop biodegradable nanoparticles for drug delivery. We are able to encapsulate several types of drug products ranging from small molecules to macromolecules such as peptides and proteins into nanoparticles. The nanoparticles can be engineered to confer a variety of characteristics including increased solubility, targeted drug delivery, long-term controlled drug release, pH-specific drug release, and increased permeability and bioavailability.

ImQuest BioSciences' capabilities in nanoparticle formulation include:

  • R&D nanoparticle encapsulation and manufacturing
  • PharmaSENS preformulation evaluations
  • Particle size analysis
  • Nanoparticle formulation characterization
  • In vitro and ex vivo drug release
  • Formulation dissolution evaluations
ImQuest BioSciences is a preclinical contract research and development organization (CRO) that provides service to evaluate the potential efficacy of new and novel pharmaceutical products for the treatment and prevention of viruses, bacteria, cancer and inflammatory disease, including in vitro toxicology and product formulation services.