PharmaSENS

Pharmaceutical Characterization and Analytical Chemistry Services

ImQuest BioSciences has integrated medicinal chemistry, LC-MS analytical and bioanalytical chemistry and NMR services as a component of our PharmaSENS platform to enable the rapid development of a safe, effective, and successful pharmaceutical products. These services are available for small molecules, natural products, oligonucleotides and other biologic products. Our synergistic approach helps facilitate more rapid movement of a potential drug from hit to lead screening, to candidate identification, and IND-directed in vitro/in vivo studies. PharmaSENS allows the optimization of a pharmaceutical product identified in efficacy and toxicity screening and provides ongoing support for PK/PD studies. Contact us to learn more.

Medicinal Chemistry Services

With decade of experience, our professional and technical team has expertise in diverse therapeutic areas including hit-to-lead evaluation and validation, to lead selection and IND-enabling preclinical development. Our medicinal chemistry services include the following:

  • Design & synthesize new analogs
  • Develop Intellectual Property
  • Patent expansion on current commercially available or clinical stage molecules
  • "Patent evergreening" / analysis
  • Computational chemistry support
  • Competitive analysis
  • Product development support from bench to clinic
  • Troubleshooting specific optimization issues including impurity profile analysis
  • Creating compound candidate profiles

Bioanalytical Chemistry

  • Proprietary assays and method development to analyze a wide range of samples including but not limited to:
    • Blood Plasma
    • Serum
    • Tissue
    • Urine
    • Feces
    • Raw Materials
    • Formulated Products
    • Environmental Samples
  • Pharmacokinetics (PK) Services
    • Advanced Bioanalytical Method Development, Method Transfer and Method Qualification
    • Extensive bioanalytical capabilities for analyzing biological tissues (brain, tumor, muscle, liver, kidney, heart)
    • PK/PD models also available:
      • Antiviral infection models
      • Antimicrobial infection models
    • GLP-compliant Immunoassay Validation and Development

Analytical Chemistry Services

  • NMR Spectroscopy Capabilities
    • We provide NMR Spectroscopy as part of our R&D and GMP – GLP services utilizing a Bruker 400 MHz spectrometer:
      • 1-Dimensional Experiments: 1H, 13C, 19F, 31P, 29Si, 15N, 11B, DEPT, NOE and more
      • 2-Dimensional Experiments: COSY and NOESY (1H-1H) , HSQC and HMBC (typically 1H-13C), DOSY and more
      • Variable temperature (-120°C to 120°C)
    • Utilize these Services to
      • Identify impurities by HPLC and LCMS
      • Isolate an impurity by prep-HPLC or flash chromatography
      • Characterize an impurity by NMR and exact mass spectrometry
      • Confirm the identity of an impurity by organic synthesis:
  • Liquid Chromatography Mass Spectrometry (LC-MS/MS) Capabilities
    • Rapid, robust and sensitive detection of a wide range of molecules in environmental and biologic samples
    • Support for in vivo PK studies
    • Advantages of Tandem LC-MS (LC-MS/MS)
      • Enhanced precision and sensitivity
      • Uses dual mass detectors to filter and detect byproducts
      • Increased specificity of analyte identification and reduced limit of detection
      • Essential to applications in the fields of drug metabolism, pharmacokinetics, and biological analyses
      • Expands our efficiency and throughput in experiments involving the analysis of urine, plasma, and other tissue samples

ImQuest BioSciences is a preclinical contract research and development organization (CRO) that provides service to evaluate the potential efficacy of new and novel pharmaceutical products for the treatment and prevention of viruses, bacteria, cancer and inflammatory disease, including in vitro toxicology and pharmaceutical product characterization services.