ImQuest CRO HIV Preclinical antiviral anticancer

Oncology Services

Anti-Cancer Discover and Development Capabilities

Our anti-cancerĀ servicesĀ facilitates the development of novel agents using our cell-based anti-cancer screening program. This platform charcterizes the mechanism of action of new products using cell-based, biochemical, immunologic, and genomic and proteomic based assays. The ImQuest BioSciences' staff has decades of experience with the efficient and cost-effective development of chemotherapeutic agents for the treatment of cancer. Request a quote for Oncology Services.

ImQuest BioSciences performs the following anti-cancer product development services:

Anti-Proliferative Screening Assays

  • Cell-based anti-cancer activity evaluations using the ImQuest BioSciences' OncoSENS platform, which consists of 120 cancer cell lines for the screening of small molecules and biologics
  • Clonogenic assays to complement the anti-proliferative assays, differentiating between cytotoxic and cytostatic modes of action
  • Biochemical and molecular target-based screening assays

Mechanism of Action Evaluations in Cell-based, Immunologic, and Biochemical Assays

  • Direct evaluation of specific inhibitory pathways: cell cycle arrest, apoptosis, kinases, growth factors and signal transduction
  • Resistance selection an characterization of resistant clones
  • Inhibitory pathway validation using binding studies, qPCR, IHC, siRNA, microarrays and flow cytometry
  • Immunophenotyping and cytokine analysis using state-of-the art multi-color flow cytometer, ELISA and cytokine profiling

Evaluation of Combination Anti-Cancer Therapeutic Approaches

  • Statistical analysis of drug combination effects using highly sensitive checkerboard evaluations

Rodent Xenograft and Other In Vivo Models of Compound Efficacy

Evaluation of Off-Target Effects and Safety Profiling

  • Screening for potential toxicity of lead therapeutics in primary cell lines
  • Screening for immune-toxic effects
  • Identification of biomarkers in the preclinical or clinical setting
  • Support for pharmacokinetic/pharmacodynamic studies, and immunogenicity
ImQuest BioSciences is a preclinical contract research and development organization (CRO) that provides service to evaluate the potential efficacy of new and novel pharmaceutical products for the treatment and prevention of viruses, bacteria, cancer and inflammatory disease, including in vitro toxicology and pharmaceutical product characterization services.