Publication in Antimicrobial Agents and Chemotherapy: Development of Dual-Acting Pyrimidinediones as Novel and Highly Potent Topical Anti-HIV Microbicides

November 1, 2011

Karen W. Buckheit, Director of Topical Microbicide Development and STI Research has published a manuscript with co-authors Dr. Robert W. Buckheit Jr. and Dr. Lu Yang entitled “Development of Dual-Acting Pyrimidinediones as Novel and Highly Potent Topical Anti-HIV Microbicides” which was published in Antimicrobial Agents and Chemotherapy (2011, 55(11), 5243-5254, PMCID: 3195032). The data presented therein discusses the activity of 12 pyrimindinedione molecules in specific HIV microbicide assays and justifies a rationale for the continued development of IQP-0528 as the lead microbicide candidate. The data generated was supported by a NIH Phase I Small Business grant that was won by Dr. Buckheit in 2008.

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