Microbicides Presentations: “Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection”

April 1, 2012

At the Microbicides 2012 meeting held in Sydney, Australia, ImQuest BioSciences presented the results of two projects in formulation development for novel microbicides. The first project entitled “Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection” presented the results of the formulation of a dual combination gel involving Tenofovir and the ImQuest drug IQP-0528. The results of the project, also published in the Journal of Pharmaceutical Sciences, showed the quantitative assessment of the various combination gel formulations to identify a lead combination IQP-0528 and tenofovir gel formulation that has significant potential to prevent infection of HIV-1. The promising development of the combination gel formulation warrants further development and is in preparation for animal safety and efficacy trials. The second presented project entitled “A Nanoparticle Based Targeted Drug Delivery System for a Combination Microbicide Product” detailed the results nanoparticle drug delivery system that can actively target HIV areas of infection and selectively delivery a combination of drugs. Targeted nanoparticles are a potential formulation strategy for combination microbicide delivery. These results demonstrate that IQP-0528 can be readily encapsulated and ISIS5320 can be conjugated to pH labile tethers onto targeting nanoparticles. The novel construction of the TDDS also allows for the modular substitution of the targeting ligand and both microbicides suggesting that such controlled targeted delivery system may be advantageous and necessary in microbicide delivery.

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