ICAR Presentation/MIP V Grant: Development of Antimicrobial Peptides as Topical Microbicides for the Prevention of HIV

May 1, 2011

Karen Watson, Director of Topical Microbicide and STI Research, presented a poster entitled “Development of Antimicrobial Peptides as Topical Microbicides for the Prevention of HIV” at the 2011 International Conference for Antiviral Research (ICAR) in Sofia, Bulgaria. The work was performed in collaboration with Dr. Guangshun Wang and the University of Nebraska and details the chemical and biological characterization of lead antimicrobial peptides that are being designed to be used as vaginal and/or rectal microbicides for the prevention of HIV. The work was funded by a Microbicide Innovation Program grant won by Dr. Robert W. Buckheit, Jr. and Dr. Wang in 2010. This work is also described in a publication by Wang, Buckheit and Watson titled, “Identification of Novel Human Immunodeficiency Virus Type-1 Inhibitory Peptides Based on the Antimicrobial Peptide Database” which was published in AAC (54 (3), 2010, p 1343-6 It discusses the specificity of chemical modifications to naturally occurring peptides and their effects on HIV activity.

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